Publications

Safety and Clinical Effects of Mesenchymal Stem Cells Secreting Neurotrophic Factor Transplantation in Patients With Amyotrophic Lateral Sclerosis

Jama Neurology, 2016

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miRNA profiling of NurOwn®: mesenchymal stem cells secreting neurotrophic factors

Stem Cell Research & Therapy, 2017

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Long term beneficial effect of neurotrophic factors-secreting mesenchymal stem cells transplantation in the BTBR mouse model of autism

Behavioural Brain Research, 2017

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Concise Review: Mesenchymal Stem Cells in Neurodegenerative Diseases

Rotem Volkman, Daniel Offen
STEM CELLS 2017;35:1867–1880

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Safety of repeated transplantations of neurotrophic factors-secreting human mesenchymal stromal stem cells

Clin Transl Nerve, 2014

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Rare combination of myasthenia and motor neuronopathy, responsive to Msc-Ntf stem cell therapy

Muscle Nerve, 2014

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Intrastriatal transplantation of neurotrophic factor-secreting human mesenchymal stem cells improves motor function and extends survival in R6/2 transgenic mouse model for Huntington’s disease

PLoS Curr, 2012

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Mesenchymal stem cells induced to secrete neurotrophic factors attenuate quinolinic acid toxicity: a potential therapy for Huntington’s disease

Sadan O, Shemesh N, Barzilay R, Dadon-Nahum M, Blumenfeld-Katzir T, Assaf Y, Yeshurun M, Djaldetti R, Cohen Y, Melamed E, Offen
Exp Neurol. 2012 Apr;234(2):417-27. doi: 10.1016/j.expneurol.2011.12.045. Epub 2012 Jan 20.
Huntington's disease (HD) is a hereditary, progressive and ultimately fatal neurodegenerative disorder.

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Differentiated mesenchymal stem cells for sciatic nerve injury

Dadon-Nachum M, Sadan O, Srugo I, Melamed E, Offen
Stem Cell Rev. 2011 Sep;7(3):664-71. doi: 10.1007/s12015-010-9227-1.
Sciatic nerve injury is common and may cause neurological deficits.

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Intravitreal injections of neurotrophic factors secreting mesenchymal stem cells are neuroprotective in rat eyes following optic nerve transection

Levkovitch-Verbin H, Sadan O, Vander S, Rosner M, Barhum Y, Melamed E, Offen D, Melamed S.
Invest Ophthalmol Vis Sci. 2010 Dec;51(12):6394-400. doi: 10.1167/iovs.09-4310. Epub 2010 Oct 6.
Rat and human bone marrow-derived mesenchymal stem cells (MSCs) were induced to secrete high levels of NTF.

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Intracerebroventricular transplantation of human mesenchymal stem cells induced to secrete neurotrophic factors attenuates clinical symptoms in a mouse model of multiple sclerosis

J Mol Neurosci, 2010

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Protective effects of neurotrophic factor-secreting cells in a 6-OHDA rat model of Parkinson disease

Stem Cells and Development, 2009

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Adult neurotrophic factor-secreting stem cells: a potential novel therapy for neurodegenerative diseases

Sadan O, Shemesh N, Cohen Y, Melamed E, Offen
Isr Med Assoc J. 2009 Apr;11(4):201-4.
Stem cell-based therapy is a promising approach for the treatment of neurodegenerative disease.

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Induction of adult human bone marrow mesenchymal stromal cells into functional astrocyte-like cells: potential for restorative treatment in Parkinson’s disease

J Mol Neurosci, 2009

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Migration of neurotrophic factors-secreting mesenchymal stem cells toward a quinolinic acid lesion as viewed by magnetic resonance imaging

Sadan O, Shemesh N, Barzilay R, Bahat-Stromza M, Melamed E, Cohen Y, Offen
Stem Cells. 2008 Oct;26(10):2542-51. doi: 10.1634/stemcells.2008-0240. Epub 2008 Jul 17.
Stem cell-based treatment is a promising frontier for neurodegenerative diseases.

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