Safety and Clinical Effects of Mesenchymal Stem Cells Secreting Neurotrophic Factor Transplantation in Patients With Amyotrophic Lateral Sclerosis
Jama Neurology, 2016
miRNA profiling of NurOwn®: mesenchymal stem cells secreting neurotrophic factors
Stem Cell Research & Therapy, 2017
Long term beneficial effect of neurotrophic factors-secreting mesenchymal stem cells transplantation in the BTBR mouse model of autism
Behavioural Brain Research, 2017
Concise Review: Mesenchymal Stem Cells in Neurodegenerative Diseases
Rotem Volkman, Daniel Offen
STEM CELLS 2017;35:1867–1880
Safety of repeated transplantations of neurotrophic factors-secreting human mesenchymal stromal stem cells
Clin Transl Nerve, 2014
Rare combination of myasthenia and motor neuronopathy, responsive to Msc-Ntf stem cell therapy
Muscle Nerve, 2014
Intrastriatal transplantation of neurotrophic factor-secreting human mesenchymal stem cells improves motor function and extends survival in R6/2 transgenic mouse model for Huntington’s disease
PLoS Curr, 2012
Mesenchymal stem cells induced to secrete neurotrophic factors attenuate quinolinic acid toxicity: a potential therapy for Huntington’s disease
Sadan O, Shemesh N, Barzilay R, Dadon-Nahum M, Blumenfeld-Katzir T, Assaf Y, Yeshurun M, Djaldetti R, Cohen Y, Melamed E, Offen
Exp Neurol. 2012 Apr;234(2):417-27. doi: 10.1016/j.expneurol.2011.12.045. Epub 2012 Jan 20.
Huntington's disease (HD) is a hereditary, progressive and ultimately fatal neurodegenerative disorder.
Differentiated mesenchymal stem cells for sciatic nerve injury
Dadon-Nachum M, Sadan O, Srugo I, Melamed E, Offen
Stem Cell Rev. 2011 Sep;7(3):664-71. doi: 10.1007/s12015-010-9227-1.
Sciatic nerve injury is common and may cause neurological deficits.
Intravitreal injections of neurotrophic factors secreting mesenchymal stem cells are neuroprotective in rat eyes following optic nerve transection
Levkovitch-Verbin H, Sadan O, Vander S, Rosner M, Barhum Y, Melamed E, Offen D, Melamed S.
Invest Ophthalmol Vis Sci. 2010 Dec;51(12):6394-400. doi: 10.1167/iovs.09-4310. Epub 2010 Oct 6.
Rat and human bone marrow-derived mesenchymal stem cells (MSCs) were induced to secrete high levels of NTF.
Intracerebroventricular transplantation of human mesenchymal stem cells induced to secrete neurotrophic factors attenuates clinical symptoms in a mouse model of multiple sclerosis
J Mol Neurosci, 2010
Protective effects of neurotrophic factor-secreting cells in a 6-OHDA rat model of Parkinson disease
Stem Cells and Development, 2009
Adult neurotrophic factor-secreting stem cells: a potential novel therapy for neurodegenerative diseases
Sadan O, Shemesh N, Cohen Y, Melamed E, Offen
Isr Med Assoc J. 2009 Apr;11(4):201-4.
Stem cell-based therapy is a promising approach for the treatment of neurodegenerative disease.
Induction of adult human bone marrow mesenchymal stromal cells into functional astrocyte-like cells: potential for restorative treatment in Parkinson’s disease
J Mol Neurosci, 2009
Migration of neurotrophic factors-secreting mesenchymal stem cells toward a quinolinic acid lesion as viewed by magnetic resonance imaging
Sadan O, Shemesh N, Barzilay R, Bahat-Stromza M, Melamed E, Cohen Y, Offen
Stem Cells. 2008 Oct;26(10):2542-51. doi: 10.1634/stemcells.2008-0240. Epub 2008 Jul 17.
Stem cell-based treatment is a promising frontier for neurodegenerative diseases.