Safety and Clinical Effects of Mesenchymal Stem Cells Secreting Neurotrophic Factor Transplantation in Patients With Amyotrophic Lateral Sclerosis Results of Phase 1/2 and 2a Clinical Trials
Panayiota Petrou, MD1; Yael Gothelf, PhD2; Zohar Argov, MD1; Marc Gotkine, MD1; Yossef S. Levy, PhD2; Ibrahim Kassis, PhD1; Adi Vaknin-Dembinsky, MD1; Tamir Ben-Hur, MD1; Daniel Offen, PhD2,3; Oded Abramsky, MD1; Eldad Melamed, MD†2,4; Dimitrios Karussis, MD, PhD1
JAMA Neurol. Published online January 11, 2016. doi:10.1001/jamaneurol.2015.4321
Safety of repeated transplantations of neurotrophic factors-secreting human mesenchymal stromal stem cells
Gothelf Y, Abramov N, Harel A, Offen
Clin Transl Med. 2014 Jul 10;3:21. doi: 10.1186/2001-1326-3-21. eCollection 2014.
Therapies based on mesenchymal stem cells (MSC) have been shown to have potential benefit in several clinical studies.
Rare combination of myasthenia and motor neuronopathy, responsive to Msc-Ntf stem cell therapy
Petrou P, Argov A, Lennon VA, Gotkine M, Kassis I, Vaknin-Dembinsky A, Ben-Hur T, Offen D, Abramsky O, Melamed E, Karussis D.
Muscle Nerve. 2014 Mar;49(3):455-7. doi: 10.1002/mus.24143. Epub 2014 Jan 20.
Intrastriatal transplantation of neurotrophic factor-secreting human mesenchymal stem cells improves motor function and extends survival in R6/2 transgenic mouse model for Huntington’s disease
Sadan O, Melamed E, Offen
PLoS Curr. 2012 Jul 10;4:e4f7f6dc013d4e. doi: 10.1371/4f7f6dc013d4e.
Stem cell-based treatment for Huntington's disease (HD) is an expanding field of research.
Mesenchymal stem cells induced to secrete neurotrophic factors attenuate quinolinic acid toxicity: a potential therapy for Huntington’s disease
Sadan O, Shemesh N, Barzilay R, Dadon-Nahum M, Blumenfeld-Katzir T, Assaf Y, Yeshurun M, Djaldetti R, Cohen Y, Melamed E, Offen
Exp Neurol. 2012 Apr;234(2):417-27. doi: 10.1016/j.expneurol.2011.12.045. Epub 2012 Jan 20.
Huntington's disease (HD) is a hereditary, progressive and ultimately fatal neurodegenerative disorder.
Differentiated mesenchymal stem cells for sciatic nerve injury
Dadon-Nachum M, Sadan O, Srugo I, Melamed E, Offen
Stem Cell Rev. 2011 Sep;7(3):664-71. doi: 10.1007/s12015-010-9227-1.
Sciatic nerve injury is common and may cause neurological deficits.
Intravitreal injections of neurotrophic factors secreting mesenchymal stem cells are neuroprotective in rat eyes following optic nerve transection
Levkovitch-Verbin H, Sadan O, Vander S, Rosner M, Barhum Y, Melamed E, Offen D, Melamed S.
Invest Ophthalmol Vis Sci. 2010 Dec;51(12):6394-400. doi: 10.1167/iovs.09-4310. Epub 2010 Oct 6.
Rat and human bone marrow-derived mesenchymal stem cells (MSCs) were induced to secrete high levels of NTF.
Intracerebroventricular transplantation of human mesenchymal stem cells induced to secrete neurotrophic factors attenuates clinical symptoms in a mouse model of multiple sclerosis
Barhum Y, Gai-Castro S, Bahat-Stromza M, Barzilay R, Melamed E, Offen
J Mol Neurosci. 2010 May;41(1):129-37. doi: 10.1007/s12031-009-9302-8. Epub 2009 Nov 10.
Stem cell-based therapy holds great potential for future treatment of multiple sclerosis (MS).
Protective effects of neurotrophic factor-secreting cells in a 6-OHDA rat model of Parkinson disease
Sadan O, Bahat-Stromza M, Barhum Y, Levy YS, Pisnevsky A, Peretz H, Ilan AB, Bulvik S, Shemesh N, Krepel D, Cohen Y, Melamed E, Offen D.
Stem Cells Dev. 2009 Oct;18(8):1179-90. doi: 10.1089/scd.2008.0411.
The prenylation of several proteins involved in oncogenesis and signal transduction plays an essential role in regulating their biological activities.
Adult neurotrophic factor-secreting stem cells: a potential novel therapy for neurodegenerative diseases
Sadan O, Shemesh N, Cohen Y, Melamed E, Offen
Isr Med Assoc J. 2009 Apr;11(4):201-4.
Stem cell-based therapy is a promising approach for the treatment of neurodegenerative disease.
Induction of adult human bone marrow mesenchymal stromal cells into functional astrocyte-like cells: potential for restorative treatment in Parkinson’s disease
Bahat-Stroomza M, Barhum Y, Levy YS, Karpov O, Bulvik S, Melamed E, Offen
J Mol Neurosci. 2009 Sep;39(1-2):199-210. doi: 10.1007/s12031-008-9166-3. Epub 2009 Jan 6.
Parkinson's disease (PD) is a neurodegenerative disorder with its motor phenomena due mostly to loss of dopamine-producing neurons in the substantia nigra.
Migration of neurotrophic factors-secreting mesenchymal stem cells toward a quinolinic acid lesion as viewed by magnetic resonance imaging
Sadan O, Shemesh N, Barzilay R, Bahat-Stromza M, Melamed E, Cohen Y, Offen
Stem Cells. 2008 Oct;26(10):2542-51. doi: 10.1634/stemcells.2008-0240. Epub 2008 Jul 17.
Stem cell-based treatment is a promising frontier for neurodegenerative diseases.